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Download. NK-3G144 User Guide. Download. NK-3RD User Guide. Download. NK-Hub User Guide. Download. NK-IPS User Guide. Download. NK-JBX User Guide. Download. NK-NET User Guide. Download. NK-RP1 User Guide. Download. NK-VRC User Guide. NK Series Button Label Template. Download. Interested in more info? Send us a note! APKPure uses signature verification to ensure virus-free NK VPN APK downloads for you. Old Versions of NK VPN. NK VPN 12.0 MB . Download. NK VPN 12.9 MB . Download. NK VPN 4.3 MB . Download. NK VPN 1.0.4. 7.4 MB . Download. All Versions. NK VPN Alternative. Sky VPN Pro.
NK Leadership Tracker - NK PRO
Following options to be added to Additional options:--fixed-mod, to declare the base name for the channel labels and the associated amino acids--lib-fixed-mod, to in silico apply the modification declared with --fixed-mod to the library--channels, to declare the mass shifts for all the channels considered--original-mods, to prevent DIA-NN from converting the declared modifications to UniModExample for L/H SILAC labels on K and R:--fixed-mod SILAC,0.0,KR,label--lib-fixed-mod SILAC--channels SILAC,L,KR,0:0; SILAC,H,KR,8.014199:10.008269--original-modsNote that in the above SILAC is declared as label, i.e. it is not supposed to change the retention time of the peptide. It is also a zero-mass label here, as it only serves to designate the amino acids that will be labelled. What the combination of --fixed-mod and --lib-fixed-mod does here is simply put (SILAC) after each K or R in the precursor id sequence, in the internal library representation used by DIA-NN. --channels then splits each library entry into two, one with masses 0 (K) and 0 (R) added upon each occurrence of K(SILAC) or R(SILAC) in the sequence, respectively, and another one with 8.014199 (K) and 10.008269 (R).Scenario 2. The library is a regular label-free library (empirical or predicted), and multiplexing is achieved via chemical labelling with mTRAQ.Scenario 2: Step 1. Label the library in silico with mTRAQ and run the deep learning predictor to adjust spectra/RTs/IMs. For this, run DIA-NN with the input library in the Spectral library field, an Output library specified, Deep learning-based spectra, RTs and IMs prediction enabled, list of raw data files empty and the following options in Additional options:--fixed-mod mTRAQ,140.0949630177,nK--lib-fixed-mod mTRAQ--channels mTRAQ,0,nK,0:0; mTRAQ,4,nK,4.0070994:4.0070994;mTRAQ,8,nK,8.0141988132:8.0141988132--original-modsUse the .predicted.speclib file with the name corresponding to the Output library as the spectral library for the next step.Scenario 2: Step 2. Run DIA-NN with the following options:--fixed-mod mTRAQ,140.0949630177,nK--channels mTRAQ,0,nK,0:0; mTRAQ,4,nK,4.0070994:4.0070994;mTRAQ,8,nK,8.0141988132:8.0141988132--original-modsNote that --lib-fixed-mod is no longer necessary as the library generated in Step 1 already contains (mTRAQ) at the N-terminus and lysines of each peptide.Scenario 3. The library is a regular label-free library (empirical or predicted), and multiplexing is achieved via chemical labelling with a label other than mTRAQ. The reason this scenario is treated differently from Scenario 2 is that DIA-NN's in silico predictor has not been specifically trained for labels other than mTRAQ, and therefore an extra step to generate predictions is not necessary. Simply run DIA-NN as you would do in Scenario 1, except the --fixed-mod declaration will have a non-zero mass in this case and will not be a label. For example, for 5-channel dimethyl as described by Thielert et al:‐‐fixed‐mod Dimethyl, 28.0313, nK--lib-fixed-mod Dimethyl‐‐channels Dimethyl,0,nK,0:0; Dimethyl,2,nK,2.0126:2.0126; Dimethyl,4,nK,4.0251:4.0251; Dimethyl,6,nK,6.0377:6.0377; Dimethyl,8,nK,8.0444:8.0444--original-modsScenario 4. The library is an empirical DIA library generated by DIA-NN from a multiplexed DIA dataset. For example, this could be a library generated by DIA-NN in the first pass of MBR (and you'd like to reuse it to analyse the same or some other runs). The Additional options will then be the same as in Scenario 1, Scenario 2: Step 2 or Scenario 3, except (important!) --lib-fixed-mod must not be supplied.Scenario 5. The sample is a light sample with heavy spike-in proteins or peptides, that is only a small proportion of precursors should feature multiple channels. In this case, start with two unlabelled spectral libraries, one for the whole proteome, another for the spike-ins. Make sure that the RT and IM scales in those are similar and fragmentation information is likewise comparable - this will be the case if the libraries are predicted by DIA-NN. Using Editing spectral libraries make sure that (i) the whole proteome library does not contain precursors corresponding to spike-in peptides and (ii) the spike-in library has appropriate channel family tags applied to theNK Aviation Tracker - NK PRO
By STUDIO ZFree1.3Safe shield iconSafe DownloaderThe Safe Downloader downloads the app quickly and securely via FileHippo’s high-speed server, so that a trustworthy origin is ensured.In addition to virus scans, our editors manually check each download for you.Advantages of the Safe DownloaderMalware protection informs you if your download has installed additional unwanted software.Discover additional software: Test new software that are waiting to be discovered in the downloader.With us you have the choice to accept or skip additional software installs.Editors' Review · July 12, 2024Pole Plus: A Fun Trivia GamePole Plus is a free Android game developed by STUDIO Z, offering a modern twist on the classic word-guessing game. Test your knowledge across various categories like movies, music, and history in an engaging gameplay experience. The intuitive interface allows easy category selection and letter guessing, with multiple difficulty levels to suit all players. Additionally, a hint system is in place to assist when needed, enhancing the overall gameplay experience.Pole Plus stands out as an entertaining and challenging trivia game, blending knowledge-testing elements with interactive fun, making it a perfect choice for trivia enthusiasts seeking a captivating gaming experience.Pole Plus 0/1TechnicalTitlePole Plus 1.3 for AndroidRequirementsAndroid 9.0LanguageEnglishAvailable languagesEnglishRussianChineseLicenseFreeLatest updateJuly 12, 2024AuthorSTUDIO ZSHA-18f2a5c9b68788b79b21f4bba25d6f6179814573aFilenamecom-free-nk-poletwo-5-57583507-e925c362bf2e26883ca9bc8b80033930.apkProgram available in other languagesDescargar Pole PlusPole Plus herunterladen下载 Pole PlusTélécharger Pole PlusPole Plus をダウンロードするPobierz Pole PlusScaricare Pole PlusChangelogWe don’t have any change log information yet for version 1.3 of Pole Plus. Sometimes publishers take a little while to make this information available, so please check back in a few days to see. Download. NK-3G144 User Guide. Download. NK-3RD User Guide. Download. NK-Hub User Guide. Download. NK-IPS User Guide. Download. NK-JBX User Guide. Download. NK-NET User Guide. Download. NK-RP1 User Guide. Download. NK-VRC User Guide. NK Series Button Label Template. Download. Interested in more info? Send us a note!NK-JittorCV/nk-remote - GitHub
SANTA ANA, Calif., March 03, 2025 (GLOBE NEWSWIRE) -- NKGen Biotech, Inc. (Nasdaq: NKGN) (“NKGen” or the “Company”), a clinical-stage biotechnology company focused on the development and commercialization of innovative autologous and allogeneic natural killer (“NK”) cell therapeutics, today announced the administration of troculeucel, an expanded autologous NK cell therapy, in a stroke patient under a single compassionate use, Investigational New Drug (“IND”) cleared by the U.S. Food and Drug Administration (“FDA”).Stroke is the second leading cause of death and long-term disability. It is accompanied by an increase in chronic neuroinflammation that can contribute to further subsequent neurological damage. Of note is that one fifth of stroke survivors go on to develop dementia after a stroke, with an 80% higher risk of developing dementia compared to matched controls. In collaboration with Dimitri Sigounas, M.D., Associate Professor of Neurological Surgery and Amarendra K. Neppalli, M.D., Director of Transplant and Cellular Therapy at George Washington University (“GWU”) Medical Center, Washington, D.C., NKGen has begun to explore the potential therapeutic role of troculeucel in the post-stroke setting. This FDA-cleared single compassionate use IND will be the initial step towards a possible full IND application. Dosing the first stroke patient is part of NKGen’s continued efforts to explore the potential of its NK cell therapy for individuals suffering post-stroke and traumatic brain injury, especially as a means to reduce or prevent chronic neuroinflammation and damage, alongside NKGen’s positive ongoing work in Alzheimer’s and other neurodegenerative diseases.The patient will receive troculeucel infusions and undergo regular independent assessments by Dr. Sigounas at GWU Medical Center.“Neurofilament light chain (“NfL”) and glial fibrillary acidic protein (“GFAP”) are markers of brain injury which have been used to assess functional outcome in stroke patients. In our Alzheimer’s trials, we have found that troculeucel can cross the blood brain barrier to reduce cerebrospinal fluid levels of GFAP and NfL” said Paul Y. Song, M.D., Chairman and Chief Executive Officer of NKGen. “We believe that troculeucel could potentially be a novel approach to reduce chronic neuroinflammation and the associated long-term sequelae in the post-stroke setting.” “I am excited to explore whether enhanced NK cells can help reduce neuroinflammation in the post-stroke setting to help improve overall outcomes. If so, I believe this may be a very important first step in finding new ways to help stroke patients,” commented Dr. Sigounas.About TroculeucelTroculeucel is a novel cell-based, patient specific, ex vivo expanded autologous NK cell immunotherapeutic drug candidate. NKGen is developing troculeucel for the treatment of neurodegenerative disorders and a broad range of cancers. Troculeucel is the International Nonproprietary Name (“INN”) for SNK01 assigned by the World Health Organization (“WHO”). The WHO INN approval of troculeucel establishes a universally recognized nonproprietary drug name for Described above. I didn't even know the husband until I did intensive google searchRe: Chioma Chukwuka Akpotha: People Think I'm A Snob, I'm Only Shy by Nobody: 11:26am On May 06, 2018 Madam, that means you are snubby then... 1 Like Re: Chioma Chukwuka Akpotha: People Think I'm A Snob, I'm Only Shy by Pavore9: 11:27am On May 06, 2018 Our Personalities vary.Re: Chioma Chukwuka Akpotha: People Think I'm A Snob, I'm Only Shy by amakadihot87(f): 11:27am On May 06, 2018 scarramenga: lol just talk say you wan see my mama and sister pinshure so you go fit w@nk to am, oya take knock yourself out.....i wount comment on your mum cos she is not my mate....but your sis ,do you think she is in anyway in the same class with chioma's beauty? 19 Likes Re: Chioma Chukwuka Akpotha: People Think I'm A Snob, I'm Only Shy by RealAlfranco: 11:35am On May 06, 2018 scarramenga: lol just talk say you wan see my mama and sister pinshure so you go fit w@nk to am, oya take knock yourself out You see, there was absolutely no need to post your mum or sister's pictures... But since you did and I believe it's the devine plan of God, shall we then talk about your sister? 5 Likes Re: Chioma Chukwuka Akpotha: People Think I'm A Snob, I'm Only Shy by Basalt(m): 11:38am On May 06, 2018 scarramenga: lol just talk say you wan see my mama and sister pinshure so you go fit w@nk to am, oya take knock yourself outWhen will you everget sense?So you had to upload the pix of your mum and sis on a faceless forum to prove a point.SMH 13 LikesWhat is NKS? NKS 2 explained
It still has its normal functions, and this can be fixed once you upgrade it to 2-4. This was fixed in 2.1, but when the Odyssey mode was introduced, the bug was put back in, but now only the appearance is changed. This bug was fixed again in December 4, 2015.Unlimited NK Coins/MM Glitch[]When the player purchases MM with NK coins, the player won't lose MM when they buy Special Agents, nor NK coins. See: Here,or here..[]On the intro screen in BTD5, right click, then click on the play button. The play button screen will still be there, yet, if the player clicks where any of the menus would be (e.g.: special agents), that menu will be opened.10 Bug[]This rarely occurs, once the player loads a save game with a Portable Lake with Monkey Buccaneers on top of it, it will show the number ten with a hour glass next to it, as if the player is on the special mission, Short-Lived.Alarm Bug[]If The player clicks the quit button, run out of lives, then click yes, an alarm will sound until the player plays, where the player gets a Game Over. This also happens in the Wizard Lord special mission when the player runs out of towers, except there is no escape from it other than reloading the game.Track 2 Bug[]If the player plays a beginner track on BTD4 and save, and when the player goes to the expansion, it will take the player to track 2 although Ninja Kiwi seems to know this as when the player does this there is a message saying that the save is from the original game and results may be unexpected. I AM ON NINJA KIWI YOU DUMB GAME! Bug when logging into the game[]The game has a system where the player canNK LiNK software support - NK Sports
BWMS Manufacturer BWMS Name Country Process Models approved Alfa Laval Tumba Pure Ballast 2.0 Pure Ballast 3.0 Sweden Filtration + Advance Oxidation Technology Pure Ballast 2.0, Pure Ballast 3.0.3.OEX, Pure Ballast 3.1/3.1EX BIO-UV GROUP BIO-SEA BWTS France Filtration + UV BIO-SEA BWTS-B06-900 COSCO Shipbuilding Industry Col, Ltd. Blue Ocean Shield China Filtration + UV BOS05-100~1600 Erma First ESK Engineering Solutions S.A. Erma First BWTS FIT / Erma First BWTS Greece Filtration + Electro-Chlorination Erma First BWTS: FIR75, FIT 100/200, FIT300, FIT400, FIT600, FIT 800, FIT1000, FIT 1200, FIT 1500, FIT 2000, FIT 2500, FIT 3000 (Filters)Erma First BWTS: 500, 800, 1000 (Cyclones) Evoqua Water Technologies, LLC SeaCURE USA Filtration + Electrolysis SEACure Models SC-1500/1, SC-F-1600-1600/2, SC-F-2000-2000/2, SC-F-3000-3000/2, SC-F-4000-4000/2, SC-F-5000-5000/2, SC-F-6000-6000/2 Evoqua Water Technologies, LLC SeaCURE USA Filtration + Electrolysis SC-F-500~6000 Ecochlor, Inc. Ecochlor BWT System USA Filtration + ClO2 Ecochlor Series 75, Series 100, Series 150, Series 200, Series 250, Series 300 Hyde Marine Inc. Hyde GUARDIAN USA Filtration + UV HG450, HG2500X Hyundai Heavy Industries HiBallast Korea Filtration + Electrolysis HiB-2000-Ex, HiB-2000, HiB-300, HiB-300-Ex, HiB-500, HiB-500-Ex, HiB-600, HiB-600-Ex, HiB-900, HiB-900-Ex, HiB-1000, HiB-1000-Ex, HiB-1200, HiB-1200-Ex, HiB-1500, Hib-1500-Ex HANLA IMS Co, Ltd. EcoGuardian Korea Filtration + Electrolysis Non-EX Proof: EG-0500/0800/1000/1500/2000EX-Proof: EG-0500-Ex/0800-Ex/1000-Ex/1500-Ex/ 2000-Ex/2600-Ex/3000-Ex HANLA IMS Co., Ltd. EcoGuardian NFTM Ballast Water Management System Korea Electro-Chlorination Non-EX Proof: EGNF0130/0250/0350/0500/0800/1000/1500/2000/2600/3000/3600/4000/5200/6000. EX-Proof: EGNF0130-Ex/0250-Ex /0350-Ex /0500-Ex /0800-Ex /1000-Ex /1500-Ex /2000-Ex /2600-Ex /3000-Ex /3600-Ex/4000-Ex /5200-Ex /6000-Ex. JFE Engineering Corporation JFE BallastAce Japan Filtration + Cl2 BallastAce-1500 Kuraray Co, Ltd. Microfade BWMS Japan Filtration + Calcium Hypochlorite MF 250~2000 Miura Co., Ltd Miura BWMS Japan Filtration + UV Miura BWMS 200 ~ 1800 m3/h NEI Treatment Systems, LLC Mitsubishi VOS System USA Deoxygenation + Cavitation VOC-500 to VOS-6500 NK Co., Ltd BlueBallast Korea Ozone + Br2 BlueBallast NK-O3-250, NK-03-150, NK-03-050 Ocean Saver AS MK II Norway Filtration + Electrolysis MK II - 3200 and 5200 m3/h Optimarin A/S Optimarin Ballast System Norway Filtration + UV OBS and OBS Ex/Models 50-3000 PANASIA CO., LTD. GloEn-Patrol Korea Filtration + UV GloEn-P250, GloEn-P300, GloEn-P350, GloEn-P500, GloEn-P700, GloEn-P750, GloEn-P750-EX, GloEn-P900, GloEn-P1000, GloEn-P1200, GloEn-P1200-EX, GloEn-P3000, GloEn-P350-EX, GloEn-P1000-EX Qingdao Headway Technology Co., Ltd Oceanguard. Download. NK-3G144 User Guide. Download. NK-3RD User Guide. Download. NK-Hub User Guide. Download. NK-IPS User Guide. Download. NK-JBX User Guide. Download. NK-NET User Guide. Download. NK-RP1 User Guide. Download. NK-VRC User Guide. NK Series Button Label Template. Download. Interested in more info? Send us a note! APKPure uses signature verification to ensure virus-free NK VPN APK downloads for you. Old Versions of NK VPN. NK VPN 12.0 MB . Download. NK VPN 12.9 MB . Download. NK VPN 4.3 MB . Download. NK VPN 1.0.4. 7.4 MB . Download. All Versions. NK VPN Alternative. Sky VPN Pro.NK Pro: Missile Tracker - NK News
SAS Zombie Assault Tower Defense is an SAS game created on June 17, 2012. In SAS: Zombie Assault 3, you save SAS Zombie Assault TD progress with your MochiGames account (before MochiCoins were discounted). In SAS ZA TD, you save progress with a NinjaKiwi account.Gameplay[]Modes[]In each map, there used to be three modes, Normal, Elite, and Nightmare. A new update added Apocalypse Mode. Apocalypse mode is a never-ending wave of zombies. The player keeps defending until he loses all of his civilian lives. All modes award the player hundreds of SAS dollars except for Apocalypse.Normal[]Normal mode is the easiest mode. It is also the only mode for new registered players. Each Normal game, the player starts with 50 civilian lives and normal zombies. There are 40 waves to beat, starting from swarm zombies on wave 1 to the ruin on wave 40. When all waves are finished, the player is awarded 10 points for the NK account, the SAS dollars, a "bronze medal" award, and unlocks the next map and Elite mode. Also, the Mamushkas have three stages rather than four in SAS3.Elite[]Elite mode is slightly harder than Normal. There are 50 waves and 40 civilian lives. The zombies have more health and are more powerful. The Mamushkas receive the fourth stage in Elite. The key to beat Elite and Nightmare with ease is to have Titanium Anti-Tank Barricades as protection. Winning Elite awards more SAS dollars than Normal and gives a silver medal award. The player is also awarded 25 Ninja Kiwi points to the user.Nightmare[]Nightmare is a difficult mode. The player must beat 60 waves with 30 civilian lives to protect. Again, a player should use Titanium Anti-Tank Barricades. Nightmare awards the largest amount of SAS dollars and 50 NK points. It also comes with a gold medal. If the player manages to beat wave 100 in freeplay mode, the player receives an achievement and some NK points. If a player beats wave 100 in "Shop 'till You Drop," he earns an achievement called "Parking Lot Punishments."Apocalypse[]Like above, Apocalypse never ends. The player has Elite Mode settings, 40Comments
Following options to be added to Additional options:--fixed-mod, to declare the base name for the channel labels and the associated amino acids--lib-fixed-mod, to in silico apply the modification declared with --fixed-mod to the library--channels, to declare the mass shifts for all the channels considered--original-mods, to prevent DIA-NN from converting the declared modifications to UniModExample for L/H SILAC labels on K and R:--fixed-mod SILAC,0.0,KR,label--lib-fixed-mod SILAC--channels SILAC,L,KR,0:0; SILAC,H,KR,8.014199:10.008269--original-modsNote that in the above SILAC is declared as label, i.e. it is not supposed to change the retention time of the peptide. It is also a zero-mass label here, as it only serves to designate the amino acids that will be labelled. What the combination of --fixed-mod and --lib-fixed-mod does here is simply put (SILAC) after each K or R in the precursor id sequence, in the internal library representation used by DIA-NN. --channels then splits each library entry into two, one with masses 0 (K) and 0 (R) added upon each occurrence of K(SILAC) or R(SILAC) in the sequence, respectively, and another one with 8.014199 (K) and 10.008269 (R).Scenario 2. The library is a regular label-free library (empirical or predicted), and multiplexing is achieved via chemical labelling with mTRAQ.Scenario 2: Step 1. Label the library in silico with mTRAQ and run the deep learning predictor to adjust spectra/RTs/IMs. For this, run DIA-NN with the input library in the Spectral library field, an Output library specified, Deep learning-based spectra, RTs and IMs prediction enabled, list of raw data files empty and the following options in Additional options:--fixed-mod mTRAQ,140.0949630177,nK--lib-fixed-mod mTRAQ--channels mTRAQ,0,nK,0:0; mTRAQ,4,nK,4.0070994:4.0070994;mTRAQ,8,nK,8.0141988132:8.0141988132--original-modsUse the .predicted.speclib file with the name corresponding to the Output library as the spectral library for the next step.Scenario 2: Step 2. Run DIA-NN with the following options:--fixed-mod mTRAQ,140.0949630177,nK--channels mTRAQ,0,nK,0:0; mTRAQ,4,nK,4.0070994:4.0070994;mTRAQ,8,nK,8.0141988132:8.0141988132--original-modsNote that --lib-fixed-mod is no longer necessary as the library generated in Step
2025-03-301 already contains (mTRAQ) at the N-terminus and lysines of each peptide.Scenario 3. The library is a regular label-free library (empirical or predicted), and multiplexing is achieved via chemical labelling with a label other than mTRAQ. The reason this scenario is treated differently from Scenario 2 is that DIA-NN's in silico predictor has not been specifically trained for labels other than mTRAQ, and therefore an extra step to generate predictions is not necessary. Simply run DIA-NN as you would do in Scenario 1, except the --fixed-mod declaration will have a non-zero mass in this case and will not be a label. For example, for 5-channel dimethyl as described by Thielert et al:‐‐fixed‐mod Dimethyl, 28.0313, nK--lib-fixed-mod Dimethyl‐‐channels Dimethyl,0,nK,0:0; Dimethyl,2,nK,2.0126:2.0126; Dimethyl,4,nK,4.0251:4.0251; Dimethyl,6,nK,6.0377:6.0377; Dimethyl,8,nK,8.0444:8.0444--original-modsScenario 4. The library is an empirical DIA library generated by DIA-NN from a multiplexed DIA dataset. For example, this could be a library generated by DIA-NN in the first pass of MBR (and you'd like to reuse it to analyse the same or some other runs). The Additional options will then be the same as in Scenario 1, Scenario 2: Step 2 or Scenario 3, except (important!) --lib-fixed-mod must not be supplied.Scenario 5. The sample is a light sample with heavy spike-in proteins or peptides, that is only a small proportion of precursors should feature multiple channels. In this case, start with two unlabelled spectral libraries, one for the whole proteome, another for the spike-ins. Make sure that the RT and IM scales in those are similar and fragmentation information is likewise comparable - this will be the case if the libraries are predicted by DIA-NN. Using Editing spectral libraries make sure that (i) the whole proteome library does not contain precursors corresponding to spike-in peptides and (ii) the spike-in library has appropriate channel family tags applied to the
2025-04-25By STUDIO ZFree1.3Safe shield iconSafe DownloaderThe Safe Downloader downloads the app quickly and securely via FileHippo’s high-speed server, so that a trustworthy origin is ensured.In addition to virus scans, our editors manually check each download for you.Advantages of the Safe DownloaderMalware protection informs you if your download has installed additional unwanted software.Discover additional software: Test new software that are waiting to be discovered in the downloader.With us you have the choice to accept or skip additional software installs.Editors' Review · July 12, 2024Pole Plus: A Fun Trivia GamePole Plus is a free Android game developed by STUDIO Z, offering a modern twist on the classic word-guessing game. Test your knowledge across various categories like movies, music, and history in an engaging gameplay experience. The intuitive interface allows easy category selection and letter guessing, with multiple difficulty levels to suit all players. Additionally, a hint system is in place to assist when needed, enhancing the overall gameplay experience.Pole Plus stands out as an entertaining and challenging trivia game, blending knowledge-testing elements with interactive fun, making it a perfect choice for trivia enthusiasts seeking a captivating gaming experience.Pole Plus 0/1TechnicalTitlePole Plus 1.3 for AndroidRequirementsAndroid 9.0LanguageEnglishAvailable languagesEnglishRussianChineseLicenseFreeLatest updateJuly 12, 2024AuthorSTUDIO ZSHA-18f2a5c9b68788b79b21f4bba25d6f6179814573aFilenamecom-free-nk-poletwo-5-57583507-e925c362bf2e26883ca9bc8b80033930.apkProgram available in other languagesDescargar Pole PlusPole Plus herunterladen下载 Pole PlusTélécharger Pole PlusPole Plus をダウンロードするPobierz Pole PlusScaricare Pole PlusChangelogWe don’t have any change log information yet for version 1.3 of Pole Plus. Sometimes publishers take a little while to make this information available, so please check back in a few days to see
2025-04-21SANTA ANA, Calif., March 03, 2025 (GLOBE NEWSWIRE) -- NKGen Biotech, Inc. (Nasdaq: NKGN) (“NKGen” or the “Company”), a clinical-stage biotechnology company focused on the development and commercialization of innovative autologous and allogeneic natural killer (“NK”) cell therapeutics, today announced the administration of troculeucel, an expanded autologous NK cell therapy, in a stroke patient under a single compassionate use, Investigational New Drug (“IND”) cleared by the U.S. Food and Drug Administration (“FDA”).Stroke is the second leading cause of death and long-term disability. It is accompanied by an increase in chronic neuroinflammation that can contribute to further subsequent neurological damage. Of note is that one fifth of stroke survivors go on to develop dementia after a stroke, with an 80% higher risk of developing dementia compared to matched controls. In collaboration with Dimitri Sigounas, M.D., Associate Professor of Neurological Surgery and Amarendra K. Neppalli, M.D., Director of Transplant and Cellular Therapy at George Washington University (“GWU”) Medical Center, Washington, D.C., NKGen has begun to explore the potential therapeutic role of troculeucel in the post-stroke setting. This FDA-cleared single compassionate use IND will be the initial step towards a possible full IND application. Dosing the first stroke patient is part of NKGen’s continued efforts to explore the potential of its NK cell therapy for individuals suffering post-stroke and traumatic brain injury, especially as a means to reduce or prevent chronic neuroinflammation and damage, alongside NKGen’s positive ongoing work in Alzheimer’s and other neurodegenerative diseases.The patient will receive troculeucel infusions and undergo regular independent assessments by Dr. Sigounas at GWU Medical Center.“Neurofilament light chain (“NfL”) and glial fibrillary acidic protein (“GFAP”) are markers of brain injury which have been used to assess functional outcome in stroke patients. In our Alzheimer’s trials, we have found that troculeucel can cross the blood brain barrier to reduce cerebrospinal fluid levels of GFAP and NfL” said Paul Y. Song, M.D., Chairman and Chief Executive Officer of NKGen. “We believe that troculeucel could potentially be a novel approach to reduce chronic neuroinflammation and the associated long-term sequelae in the post-stroke setting.” “I am excited to explore whether enhanced NK cells can help reduce neuroinflammation in the post-stroke setting to help improve overall outcomes. If so, I believe this may be a very important first step in finding new ways to help stroke patients,” commented Dr. Sigounas.About TroculeucelTroculeucel is a novel cell-based, patient specific, ex vivo expanded autologous NK cell immunotherapeutic drug candidate. NKGen is developing troculeucel for the treatment of neurodegenerative disorders and a broad range of cancers. Troculeucel is the International Nonproprietary Name (“INN”) for SNK01 assigned by the World Health Organization (“WHO”). The WHO INN approval of troculeucel establishes a universally recognized nonproprietary drug name for
2025-03-30